Do Concurrent Multiple Infections with High-Risk HPVs Carry a More Malignant Potential than a Single Infection in the Uterine Cervix?

The high-risk human papillomavirus (HR-HPV) has been known as the most important carcinogen in uterine cervical carcinoma. However, there is limited evidence of malignant potential these concurrent multiple infections. This study included women who had undergone conization. They underwent an HPV test by swab within 12 months before surgery. were divided into two groups: one with a single infection HR-HPV16 and other infections HR-HPVs, including genotype 16. Pathologic examination classified cases CIS+ to assess compare both groups, carcinoma situ (CIS) invasive Of 220 patients infected HR-HPV16, group consisted 120 (54.5%), whereas 100 (45.5%) patients. rates HSIL significantly higher group. odds ratio for did not show significant difference between groups (1.417, 95% CI = 0.831–2.414, p 0.200). was different 16, 16 Korean women.